Pathogenesis of Vitamin K Deficiency in Newborn Infants

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Administration of vitamin K to newborn infants and childhood cancer.

OBJECTIVES To investigate whether childhood cancer is associated with intramuscular administration of vitamin K to newborn infants. DESIGN Routines for administration of vitamin K to infants born after normal deliveries during 1973-89 were obtained from maternity hospitals. Occurrence of cancer up to the end of 1991 was identified by comparing these records with the national cancer registry. ...

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[Prophylactic vitamin K for vitamin K deficiency bleeding of the newborn].

BACKGROUND The administration of vitamin K immediately after birth has shown a significant decrease in the incidence of newborn bleeding, but there is not enough evidence to determine the most appropriate method of administration. The objective of this review is to determine the effectiveness of orally administered vitamin K compared to the intramuscular route in the prevention of hemorrhagic d...

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Late Vitamin K Deficiency Bleeding in Infants Whose Parents Declined Vitamin K Prophylaxis — Tennessee, 2013

Vitamin K deficiency bleeding (VKDB) is a coagulopathy that develops in infants who do not have sufficient vitamin K stores to support production of clotting factors. In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in humans is limited; cord blood and infant liver reserve levels of vitamin K are substantially below adult lev...

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Pathogenesis of intraventricular haemorrhage in newborn infants.

an intraventricular haemorrhage (IVH) was also present. After consideration of the clinical features ofthe infants, their coagulation status, and the findings at necropsy, we suggest that increased cerebral venous and capillary pressure, usually caused by heart failure resulting from hypoxia and acidosis, was responsible both for the IVH, by rupturing the terminal veins, and for promoting the f...

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Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.

Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations for the prevention...

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ژورنال

عنوان ژورنال: Journal of Nutritional Science and Vitaminology

سال: 1992

ISSN: 0301-4800,1881-7742

DOI: 10.3177/jnsv.38.special_409